Abstract This chapter focuses on "chromatographic" issues, leading to irregularities in the chromatogram such as retention shifts, peak overlaps, bleeding, ghost peaks, bad peak shapes, changing response or disappearing peaks.
KeywordsTroubleshooting GC.
LevelBasic
What can go wrong in GC?
A few of the often occurring types of problems are listed hereunder. Some can be related to the GC itself, such as thermal, electronical and mechanical problems. We focus in this chapter on solving the chromatographic failures.
| Type of problem | Culprit |
| Chromatographic |
Carrier gas Dead Volume Column |
| Chemical | Carrier gas Column/Stationary Phase Sample Detector |
| Electronical | GC Datasystem System sensors |
| Thermal | Injector Detector Oven |
| Mechanical | Pressure/Flow regulation Fittings Injectors |
| Human | Injection Sample Preparation |
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