What might precision medicine look like in 2050? Our cover feature brings together four leading experts – Ying Ge, Neil Kelleher, Lingjun Li, and Mike Snyder – to map the road to a truly personalized healthcare future, driven by proteomics, microsampling, AI, and longitudinal monitoring. Meanwhile, “Analytical Science Under Siege” grapples with the impact of the US government’s sweeping cost-cutting measures, with views from Erin Baker, Kevin Schug, Richard Zare, and others. In our Core Topics, Chris Enke recounts the serendipitous invention of the triple quadrupole mass spectrometer, Greg Klunder shares insights into life as a nuclear forensic scientist, and we return to a decade-old question – have we reached the limits of HPLC? – with fresh insights from Fabrice Gritti, Gert Desmet, and Martina Catani. We also sit down with Chad Mirkin, who reflects on nanotech breakthroughs and molecular diagnostics. Finally, don’t miss our coverage of the environmental toll of war in Ukraine and how analytical scientists are responding to the call. click here for more