SFC for Chiral separation in Pharmaceutical Industry

Abstract The importance of methods to analyze or to separate enantiomers has increased, particularly in pharmaceutical industry. Around 50% of commercial pharmaceutical compounds and 80%[1] of compounds in research and development are chiral; the revenue from chiral technology will near $15 billion by 2009[2]. Chiral HPLC is one of the best methods for the direct separation of enantiomers using Chiral Stationary Phases (CSPs)[3]. But the advent of Supercritical Fluid Chromatography (SFC) has changed the established order. Thanks to the higher diffusivity and the lower viscosity of supercritical fluid like CO2, the resolution is improved and the analysis time is reduced. That’s why SFC becomes the prime method for chiral separation. In this chapter we will explain our strategy to develop a fast method using chiral SFC.

D.Speybrouck, S. Thomas, Janssen-Cilag Research Center, Campus de Maigremont BP 615, 27106 Val de Reuil Cedex, France


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