Abstract Chiral analysis deals with the separation, detection and quantitation of individual enantiomers, or more generally speaking of stereoisomers, of chiral compounds such as chiral drugs, agrochemicals, food additives, flavors, fragrances, pheromones, chiral synthons, catalysts, etc. For the accurate analysis of enantiomers by HPLC, GC, SFC, or CE they need to be separated because detectors frequently employed in chromatography such as UV, fluorescence or mass spectrometric detectors cannot distinguish between enantiomers. Yet, the separation of enantiomers (stereoisomers) constitutes a major challenge. The methodologies that are amenable and nowadays preferably used will be outlined.


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